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September 22, 2015Updated 12.11.23

CGS-MolDX Molecular Test Registration and Claims Submission (CM00003, Vol. 8) V2

MolDX Test Registration

To access and obtain a DEX Z-Code®, follow the steps below:

Go to the DEX® Diagnostics Exchange Registry: https://app.dexzcodes.comExternal Website

Under "Register My Organization" select Register as a Lab or Hospital and follow the prompts. You will need to have your organization’s NPI# and CLIA# available. The option to register as a Manufacturer is available for organizations with an FDA approved molecular test for which a Z-Code is applicable.

Please Note: As the registered user for an organization in the DEX Registry, the username is specific to the contact person designated by each laboratory. Please do not forward or share this information. Colleagues within your organization who want to register may apply for a public user account at https://app.dexzcodes.comExternal Website. A public user account allows a view of public information which does not include Z-Codes.

Once the DEX team has successfully reviewed the registration information submitted, you will receive a welcome email with a link to set your password and a "Getting Started" guide with information on using the DEX Registry.

After you have received the email and activated your login, you will have access to add test information.

Within approximately two weeks of adding your test into the DEX Registry, a Z-Code will be assigned to your test(s). You will receive an email notification with your assigned Z-Code(s) once complete. If the DEX team has questions regarding your test submission, we will contact you for additional information.

The assigned Z-Code is not effective for claims until the DEX clinical team has reviewed your test application and assigned a CPT® code. The CPT code you submit with your application is not necessarily the CPT code that will be assigned to your test. You will receive an email notification from DEX customer service when your test has been updated with the assigned CPT code in the DEX Registry.

If your test requires additional forms and documentation for a technical assessment (TA) review, you will receive an email notification with instructions.

For questions, email

MolDX Claim Submission

The claim line for molecular diagnostic tests must contain the appropriate CPT code and test identifier (DEX Z-Code™) associated with the test.

For CPT NOC codes, the test specific DEX Z-Code™ is submitted in the SV101-7 (5010A1-837P) or SV202-7 (5010A1-837I) claim line detail field. For CPT non-NOC codes, providers may either use the SV101-7 or SV202-7 (preferred) or the NTE field to submit this required information.

Providers billing Part A for molecular tests performed by a proprietary or reference laboratory must obtain the DEX Z-Code™ for the molecular test(s) from the performing laboratory. Part A providers billing for molecular services performed by a hospital-based laboratory must register and obtain a unique DEX Z-Code™ for each molecular test in the MolDX code ranges designated above. Part A providers will need to specify which lines are billed for MolDX and the appropriate DEX Z-Code per line within the remarks section of the claim.

For correct claims adjudication for the applicable services, enter the following information for each test submitted on the claim:

  • Enter claim line number of the performed test.
  • Enter registered test DEX Z-Code™.

Correct FISS Remarks Samples:

Sample1: ID for a test on line one

Line 1 (HCPCS) – ZB123

Sample 2: IDs for two molecular tests on line one and line two

Line 1 (HCPCS) – ZB123
Line 2 (HCPCS) – ZD456

Reviewed: 12.11.23


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