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September 22, 2015 - Updated 11.28.18

CGS-MolDX Molecular Test Registration and Claims Submission (CM00003, Vol. 7)

MolDX Test Registration

To access and obtain a DEX Z-code™ identifier, follow these simple steps:

  • Go to the DEX Diagnostics Exchange™External Website page
  • Select 'Register My Organization' and follow the prompts, including participation in the MolDX program
  • An email with a user name and a link for activating your account will be sent to you once Change Healthcare activates your account
  • Once you've completed the registration of your organization and activation of your account you will have access to add test information

DEX access enables the following functions:

  • Review specific test information
  • Review each DEX Z-Code™ Identifier
  • Request edits for tests
  • Register new tests

For questions, email MolDX@PalmettoGBA.com

As the individual listed in the DEX Z-Code™ identifier application, the username is specific to the contact person designated by each laboratory. Please do not forward or share this information. Colleagues within your organization who want to register may apply for a public user accountExternal Website. A Public user account requires a valid email address and allows a view of public information.

Within 45 business days of a complete and valid registration, the DEX Z-Code TM identifier will be assigned for tests. The MolDX team will review the registry information to determine if a test meets the Medicare criteria for coverage. For more information, please refer to MolDX Frequently Asked Questions.

MolDX Claim Submission

The claim line for molecular diagnostic tests must contain the appropriate CPT code and test identifier (DEX Z-Code™) associated with the test. Effective September 1, 2017, CPT codes 87631-87633 and 87149-87150 will require the use of a DEX Z-Code™ for Part A and Part B claims submission.

For CPT NOC codes (81479, 81599, 84999, 85999, 86849, 87999, 88199, 88299,), the test specific DEX Z-Code™ is submitted in the SV101-7 (5010A1-837P) or SV202-7 (5010A1-837I) claim line detail field. For CPT non-NOC codes, providers may either use the SV101-7 or SV202-7 (preferred) or the NTE field to submit this required information.

Providers billing Part A for molecular tests performed by a proprietary or reference laboratory must obtain the DEX Z-Code™ for the molecular test(s) from the performing laboratory. Part A providers billing for molecular services performed by a hospital-based laboratory must register and obtain a unique DEX Z-Code™ for each molecular test in the MolDX code ranges designated above. Part A providers will need to specify which lines are billed for MolDX and the appropriate DEX Z-Code per line within the remarks section of the claim.

For correct claims adjudication for the applicable services, enter the following information for each test submitted on the claim:

  • Enter claim line number of the performed test.
  • Enter registered test DEX Z-Code™.

Correct FISS Remarks Samples:

Sample1: ID for a test on line one

Line 1 (HCPCS) – ZB123

Sample 2: IDs for two molecular tests on line one and line two

Line 1 (HCPCS) – ZB123
Line 2 (HCPCS) – ZD456

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