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June 5, 2025

July 2025 HCPCS Updates – New, Revised, and Discontinued HCPCS Codes and Modifiers

The following information is based on the July 2025 Healthcare Common Procedure Coding System (HCPCS) file. There are several updates that will be effective July 1, 2025. Please keep in mind that the appearance of a HCPCS code is not an indication of coverage by the DME MAC.

This following list contains added HCPCS codes that will be effective July 1, 2025.

HCPCS DESCRIPTION
J0165 Injection, epinephrine, not otherwise specified, 0.1 mg
J0166 Injection, epinephrine (bpi), not therapeutically equivalent to j0165, 0.1 mg
J0167 Injection, epinephrine (hospira), not therapeutically equivalent to j0165, 0.1 mg
J0168 Injection, epinephrine (international medication systems), not therapeutically equivalent to j0165, 0.1 mg
J0169 Injection, epinephrine (adrenalin), not therapeutically equivalent to j0165, 0.1 mg
J0618 Injection, calcium chloride, 2 mg
J1163 Injection, diltiazem hydrochloride, 0.5 mg
J1326 Injection, zolbetuximab-clzb, 2 mg
J2312 Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
J2313 Injection, naloxone hydrochloride (zimhi), 0.01 mg
J3373 Injection, vancomycin hydrochloride, 10 mg
J3374 Injection, vancomycin hydrochloride (mylan) not therapeutically equivalent to j3373, 10 mg
J3375 Injection, vancomycin hydrochloride (xellia), not therapeutically equivalent to j3373, 10 mg
J3391 Injection, atidarsagene autotemcel, per treatment
J7172 Injection, marstacimab-hncq, 0.5 mg
J7356 Injection, foscarbidopa 0.25 mg/foslevodopa 5 mg
J9174 Injection, docetaxel (beizray), 1 mg
J9220 Injection, indigotindisulfonate sodium, 1 mg
J9275 Injection, cosibelimab-ipdl, 2 mg
J9276 Injection, zanidatamab-hrii, 2 mg
J9289 Injection, nivolumab, 2 mg and hyaluronidase-nvhy
J9341 Injection, thiotepa (tepylute), 1 mg
J9342 Injection, thiotepa, not otherwise specified, 1 mg
J9382 Injection, zenocutuzumab-zbco, 1 mg
Q2058 Obecabtagene autoleucel, 10 up to 400 million cd19 car-positive viable t cells, including leukapheresis and dose preparation procedures, per infusion

The following HCPCS codes have description/verbiage changes that will be effective July 1, 2025.

HCPCS DESCRIPTION
J1954 Injection, leuprolide acetate for depot suspension (lutrate depot), 7.5 mg
J9292 Injection, pemetrexed dipotassium, 10 mg

The following list contains discontinued HCPCS codes, along with the cross-walked HCPCS codes (if applicable). Please note, not all discontinued HCPCS codes will have a cross-walked HCPCS code.

HCPCS DISCONTINUE DATE CROSSWALK HCPCS CODE
J0171 06/30/2025  
J0173 06/30/2025  
J2310 06/30/2025  
J2311 06/30/2025  
J3370 06/30/2025  
J3371 06/30/2025  
J3372 06/30/2025  
J9340 06/30/2025  

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