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POINT AND CLICK LICENSE FOR USE OF "CURRENT DENTAL TERMINOLOGY", ("CDT")

End User License Agreement

These materials contain Current Dental Terminology, Fourth Edition (CDT), copyright © 2002, 2004 American Dental Association (ADA). All rights reserved. CDT is a trademark of the ADA.

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March 6, 2025

VYALEV® (foscarbidopa and foslevodopa), the VYAFUSER Pump, and Related Infusion Supplies - Correct Coding and Billing – Revised

Joint DME MAC Publication

VYALEV® (foscarbidopa and foslevodopa, AbbVie Inc. Chicago, IL, U.S.A) is a medication approved by the U.S. Food and Drug Administration on October 17, 2024 and is indicated for the treatment of motor fluctuations in adults with advanced Parkinson’s disease. Administration of VYALEV® is via subcutaneous administration only, preferably in the abdomen, via the VYAFUSER pump. Per the FDA prescribing information, the maximum recommended daily dosage of VYALEV is 3,525 mg of foslevodopa (approximately 2,500 mg levodopa).

Questions have arisen about the proper coding and billing of VYALEV® and the VYAFUSER pump and related infusion supplies. For dates of service on or after October 17, 2024, claims for VYALEV® must be submitted using the HCPCS code J7799 (NOC DRUGS, OTHER THAN INHALATION DRUGS, ADMINISTERED THROUGH DME). Suppliers are reminded that when submitting claims for items coded J7799, the supplier must include the following information on each claim:

  • Name of Drug
  • Manufacturer name
  • Dosage Strength

Claims for the VYAFUSER pump for dates of service before January 24, 2025 must be coded as E1399 (DURABLE MEDICAL EQUIPMENT, MISCELLANEOUS). Code E1399 is the proper code to use if a unique pump is FDA approved and does not fall under any existing pump HCPCS codes. Suppliers must include the following information on each claim when submitting claims for items coded E1399:

  • Description of the item
  • Manufacturer name
  • Product name and number
  • Supplier price list
  • HCPCS of related item

This additional information for the drugs and pump (if applicable) must be entered in the narrative field of an electronic claim (NTE 2300 or NTE 2400 of an electronic claim) or Item 19 of a paper claim. Since these miscellaneous codes are individually adjudicated, use of the KX, GA and GZ modifiers are not required.

Claims for the VYAFUSER pump and related administration supplies for dates of service on or after January 24, 2025 must be coded as follows:

Manufacturer Name Product Name Model Number HCPCS Code
PHILLIPS-MEDISIZE A/S VYAFUSER PUMP 2089870410 E0781
B BRAUN MEDICAL INC OMNIFIX SYRINGE 4617100V-02 K0552
CONVATEC NERIAGUARD INFUSION SET 704060-5226 USA A4222
WEST VIAL ADAPTER 8073051 A4222
RRC RECHARGEABLE BATTERY RRC1120-PM K0604
CONVATEC NERIAGUARD INFUSION SETS 704060-5229 USA A4222

Suppliers must use the KX modifier on claims for the VYAFUSER pump and related infusion supplies billed under HCPCS E0781, A4222, K0552 and K0604. In this situation, application of the KX modifier attests that a Standard Written Order (SWO) is on file and the medical record supports the item is reasonable and necessary. Use of the KX modifier is not required for NOC-coded pumps and drugs.

For questions about correct coding, contact the Pricing, Data Analysis and Coding (PDAC) HCPCS Helpline at (877) 735-1326 during the hours of 9:30 a.m. to 5:00 p.m. ET, Monday through Friday. You may also visit the PDAC websiteExternal Website to chat with a representative or select the Contact UsExternal Website button at the top of the PDAC website for email, FAX, or postal mail information.

Publication History

March 6, 2025 Revised to change A4221 to A4222
February 13, 2025 Originally Published

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