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March 1, 2019

Contractor Advisory Committee Tumor Treatment Field Therapy Bibliography

The following bibliography was provided to the Contractor Advisory Committee (CAC) for their consideration of Tumor Treatment Field Therapy in the treatment of newly diagnosed glioblastoma multiforme.

Submitted by Novocure with Reconsideration Request

Stupp R, Taillibert S, Kanner A, et al. Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. JAMA. 2015;314(23):2535-2543. doi:10.1001/jama.2015.16669

Stupp R, Taillibert S, Kanner A, et al. Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA. 2017;318(23):2306. doi:10.1001/jama.2017.18718 External Website

Taphoorn MJB, Dirven L, Kanner AA, et al. Influence of Treatment With Tumor-Treating Fields on Health-Related Quality of Life of Patients With Newly Diagnosed Glioblastoma: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncology. 2018;4(4):495. doi:10.1001/jamaoncol.2017.5082 External Website

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Central Nervous System Cancers. NCCN Flash Card™. Version 1.2018 March 20, 2018.

Provided by DME MACs

Bhandari M. Comparative Study of Adjuvant Temozolomide six Cycles Versus Extended 12 Cycles in Newly Diagnosed Glioblastoma Multiforme. Journal Of Clinical And Diagnostic Research. 2017. doi:10.7860/JCDR/2017/27611.9945 External Website

Cloughesy TF, Lassman AB. NovoTTF: where to go from here? Neuro-Oncology. 2017;19(5):605-608. doi:10.1093/neuonc/nox014 External Website

Food and Drug Administration. Summary of Safety and Effectiveness Data. PMA P100034. Novocure TTF-100A. April 8, 2011

Food and Drug Administration. Summary of Safety and Effectiveness Data. PMA P100034/S013. Novocure TTF-100A. October 5, 2015

Food and Drug Administration. Novocure Submission to Neurological Devices Panel. NovoTTF-100A. March 17, 2011.

Kesari S, Ram Z, on behalf of EF-14 Trial Investigators. Tumor-treating fields plus chemotherapy versus chemotherapy alone for glioblastoma at first recurrence: a post hoc analysis of the EF-14 trial. CNS Oncology. 2017;6(3):185-193. doi:10.2217/cns-2016-0049 External Website

Kirson ED, Dbaly V, Tovarys F, et al. Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors. Proceedings of the National Academy of Sciences. 2007;104(24):10152-10157. doi: 10.1073/pnas.0702916104 External Website.

Kirson ED, Gurvich Z, Schneiderman R, et al. Disruption of Cancer Cell Replication by Alternating Electric Fields. Cancer Research. 2004;64(9):3288-3295. doi: 10.1158/0008-5472.can-04-0083 External Website.

Martínez-Garcia M, Álvarez-Linera J, Carrato C, et al. SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017). Clinical and Translational Oncology. 2018;20(1):22-28. doi:10.1007/s12094-017-1763-6 External Website

Mehta M, Wen P, Nishikawa R, Reardon D, Peters K. Critical review of the addition of tumor treating fields (TTFields) to the existing standard of care for newly diagnosed glioblastoma patients. Critical Reviews in Oncology/Hematology. 2017;111:60-65. doi:10.1016/j.critrevonc.2017.01.005 External Website

Mittal S, Klinger NV, Michelhaugh SK, Barger GR, Pannullo SC, Juhász C. Alternating electric tumor treating fields for treatment of glioblastoma: rationale, preclinical, and clinical studies. Journal of Neurosurgery. February 2018:414-421. doi:10.3171/2016.9.JNS16452 External Website

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Central Nervous System Cancers. Version 2.2018 November 26, 2018. Accessed January 3, 2019.

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Central Nervous System Cancers. NCCN Evidence Blocks™. Version 2.2018 November 26, 2018. Accessed January 3, 2019.

Palmer JD, Bhamidipati D, Mehta M, et al. Treatment recommendations for elderly patients with newly diagnosed glioblastoma lack worldwide consensus. Journal of Neuro-Oncology. 2018;140(2):421-426. doi:10.1007/s11060-018-2969-3 External Website

Sampson JH. Alternating Electric Fields for the Treatment of Glioblastoma. JAMA. 2015;314(23):2511. doi:10.1001/jama.2015.16701 External Website

Sulman EP, Ismaila N, Armstrong TS, et al. Radiation Therapy for Glioblastoma: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Guideline. Journal of Clinical Oncology. 2017;35(3):361-369. doi:10.1200/JCO.2016.70.7562 External Website

Tracy Batchelor, MD, MPH, Helen A Shih, MD. Management of glioblastoma in older adults - UpToDate. :14.

Weller M, van den Bent M, Tonn JC, et al. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. The Lancet Oncology. 2017;18(6):e315-e329. doi:10.1016/S1470-2045(17)30194-8 External Website

Wick W. TTFields: where does all the skepticism come from? Neuro-Oncology. 2016;18(3):303-305. doi:10.1093/neuonc/now012 External Website

Wick W, Osswald M, Wick A, Winkler F. Treatment of glioblastoma in adults. Therapeutic Advances in Neurological Disorders. 2018;11:175628641879045. doi:10.1177/1756286418790452 External Website

Wick W, Platten M. Understanding and Treating Glioblastoma. Neurologic Clinics. 2018;36(3):485-499. doi:10.1016/j.ncl.2018.04.006 External Website

Toms SA, Kim CY, Nicholas G, Ram Z. Increased compliance with tumor treating fields therapy is prognostic for improved survival in the treatment of glioblastoma: a subgroup analysis of the EF-14 phase III trial. 2018 141:467–473. Doi: 10.1007/s11060-018-03057-z

Provided by CAC Members

Chang E, Patel CB, Pohling C, et al. Tumor treating fields increases membrane permeability in glioblastoma cells. Cell Death Discovery. 2018;4(1):1-13. doi: 10.1038/s41420-018-0130-x External Website.

Kim EH, Kim YJ, Song HS, et al. Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation. Oncotarget. 2016;7(38):62267-62279. doi: 10.18632/oncotarget.11407 External Website.

Kim EH, Song HS, Yoo SH, Yoon M. Tumor treating fields inhibit glioblastoma cell migration, invasion and angiogenesis. Oncotarget. 2016;7(40):65125-65136. doi: 10.18632/oncotarget.11372External Website.

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